FZD10

Uvojiti receptor 10
Uvojiti receptor 10
Identifikatori
Simboli	FZD10; CD350; FZ-10; Fz10; FzE7; hFz10
Vanjski ID	OMIM: 606147 MGI: 2136761 HomoloGene: 21411 IUPHAR: FZD10 GeneCards: FZD10 Gene
Ontologija gena
Molekularna funkcija	• aktivnost G protein spregnutog receptora; • receptorsko vezivanje; • proteinsko vezivanje; • Wnt proteinsko vezivanje; • vezivanje PDZ domena;
Celularna komponenta	• citoplazma; • ćelijska površina; • integralno sa membranom; • sinaptosom; • membrana neuronske projekcije;
Biološki proces	• pozitivna regulacija proteinske fosforilacije; • razvoj vaskulature; • morfogeneza odlivnog trakta; • signalni put G protein spregnutog receptora spregnutog sa cGMP nukleotidom;
Pregled RNK izražavanja
	podaci
Ortolozi
Vrsta	Čovek
Entrez	11211
Ensembl	ENSG00000111432
UniProt	Q9ULW2
RefSeq (mRNA)	NM_007197.3
RefSeq (protein)	NP_009128.1
Lokacija (UCSC)	Chr 12:; 130.65 - 130.65 Mb
PubMed pretraga	[1]

Uvojiti-10 je protein koji je kod ljudi kodiran FZD10 genom.^[1]^[2] FZD10 se takođe označava CD350 (klaster diferencijacije 350).

Članovi familije „uvojitih“ proteina su 7-transmembranski receptori za Wnt signalne proteine. FZD10 protein sadrži signalni peptid, cisteinom bogati domen u N-terminalnom ekstracelularnom regionu, 7 transmembranski domen, i C-terminalni PDZ vezujući motiv. Većina uvojitih receptora je spregnuta sa beta-kateninskim kanoničkim signalnim putem. Izražavanje ovog gena je znatno povećano ćelijama raka debelog creva.^[2]

Reference

^ Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (1999). „Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family”. Biochem Biophys Res Commun. 262 (1): 39—43. PMID 10448064. doi:10.1006/bbrc.1999.1161.
^ ^а ^б „Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)”.

Literatura

Finch PW; He X; Kelley MJ; et al. (1997). „Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action”. Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770—5. PMC 21233 . PMID 9192640. doi:10.1073/pnas.94.13.6770.
Tanaka S; Akiyoshi T; Mori M; et al. (1998). „A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 10164—9. PMC 21479 . PMID 9707618. doi:10.1073/pnas.95.17.10164.
Kumar S; Connor JR; Dodds RA; et al. (2001). „Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries”. Osteoarthr. Cartil. 9 (7): 641—53. PMID 11597177. doi:10.1053/joca.2001.0421.
Terasaki H, Saitoh T, Shiokawa K, Katoh M (2002). „Frizzled-10, up-regulated in primary colorectal cancer, is a positive regulator of the WNT - beta-catenin - TCF signaling pathway”. Int. J. Mol. Med. 9 (2): 107—12. PMID 11786918.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Omoto S; Hayashi T; Kitahara K; et al. (2004). „Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)”. Ophthalmic Genet. 25 (2): 81—90. PMID 15370539. doi:10.1080/13816810490514270.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.

Vidi još

Uvojiti receptori

Spoljašnje veze

„Frizzled Receptors: FZD₁₀”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
FZD10+protein,+human на US National Library of Medicine Medical Subject Headings (MeSH)

[pmid10448064-1] Koike J, Takagi A, Miwa T, Hirai M, Terada M, Katoh M (1999). „Molecular cloning of Frizzled-10, a novel member of the Frizzled gene family”. Biochem Biophys Res Commun. 262 (1): 39—43. PMID 10448064. doi:10.1006/bbrc.1999.1161.

[entrez-2] а ^б „Entrez Gene: FZD10 frizzled homolog 10 (Drosophila)”.

[1]

[2]

FZD10

Reference

Literatura

Vidi još

Spoljašnje veze

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