Faktor PTA
| Faktor PTA | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Pengidentifikasi | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Alias | F11, FXI, coagulation factor XI, PTA, factor XI | ||||||||||||||||||||||||||||||||||||||||||||||||||
| ID Eksternal | OMIM: 264900; MGI: 99481; HomoloGene: 86654; GeneCards: F11; OMA:F11 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Nomor EC | 3.4.21.27 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Faktor PTA atau faktor XI (bahasa Inggris: plasma thromboplastin antecedent, PTA, antihemophilic factor C, PTA factor, plasma thromboplastin factor C, PTF-C, Factor XI, FXI) adalah zimogen dari jenis serina protease yang merupakan prekursor dari faktor XIa, yang disekresi ke dalam sirkulasi darah untuk mengaktivasi plasma tromboplastin intrinsik[4] saat darah terpapar oleh permukaan asing.[5] Pada manusia, FXI terkodikasi dalam gen F11.[6][7][8][9]
FXI disintesis oleh hati dan disekresi dalam bentuk homo-dimer yang tidak aktif[10] dengan waktu paruh sekitar 52 jam dan rasio plasma sekitar 5 mcg/mL.[11]
Rujukan
- ^ a b c GRCh38: Ensembl release 89: ENSG00000088926 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ (Inggris) "Factors". Farlex free dictionary. Diarsipkan dari asli tanggal 2021-10-18. Diakses tanggal 2010-04-29.
{{cite web}}: - ^ (Inggris) "Factor XI". Answer.com. Diarsipkan dari asli tanggal 2016-03-04. Diakses tanggal 2010-04-29.
{{cite web}}: - ^ Fujikawa K, Chung DW, Hendrickson LE, Davie EW (1986). "Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein". Biochemistry. 25 (9): 2417–24. doi:10.1021/bi00357a018. PMID 3636155.
{{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link) - ^ Asakai R, Davie EW, Chung DW (1987). "Organization of the gene for human factor XI". Biochemistry. 26 (23): 7221–8. doi:10.1021/bi00397a004. PMID 2827746.
{{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link) - ^ Kato A, Asakai R, Davie EW, Aoki N (1989). "Factor XI gene (F11) is located on the distal end of the long arm of human chromosome 4". Cytogenet. Cell Genet. 52 (1–2): 77–8. doi:10.1159/000132844. PMID 2612218.
{{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link) - ^ Buetow KH, Shiang R, Yang P, Nakamura Y, Lathrop GM, White R, Wasmuth JJ, Wood S, Berdahl LD, Leysens NJ (1991). "A detailed multipoint map of human chromosome 4 provides evidence for linkage heterogeneity and position-specific recombination rates". Am. J. Hum. Genet. 48 (5): 911–25. PMC 1683054. PMID 1673289.
{{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link) - ^ Wu W, Sinha D, Shikov S, Yip CK, Walz T, Billings PC, Lear JD, Walsh PN (2008). "Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa". J. Biol. Chem. 283 (27): 18655–64. doi:10.1074/jbc.M802275200. PMID 18441012.
{{cite journal}}: Pemeliharaan CS1: Banyak nama: daftar penulis (link) Pemeliharaan CS1: DOI bebas tanpa ditandai (link) - ^ (Inggris) "Factor XI Deficiency". Cardeza Foundation Hemophilia Treatment Center, Thomas Jefferson University; Jamie E Siegel. Diarsipkan dari asli tanggal 2019-08-24. Diakses tanggal 2010-04-29.
{{cite web}}:
Pranala luar
- (Inggris) UAB Coagulation Service Diarsipkan 2010-07-03 di Wayback Machine.. Department of Pathology, UAB Hospital.
Bacaan lanjut
- (Inggris) High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis Diarsipkan 2010-03-05 di Wayback Machine.. New England Journal of Medicine; Joost C.M. Meijers, Winnie L.H. Tekelenburg, et al.
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