ADAM2
Protein 2 koji sadrži dezintegrin i metaloproteinazni domen ili Beta-fertilin[5] je enzim koji je kod ljudi kodiran genom ADAM2.[6][7][8]
Funkcija
Ovaj gen kodira člana porodice ADAM (domen dezintegrina i metaloproteinaze). Članovi ove porodice su proteini usidreni u membrani, strukturno srodni dezintegrinima zmijskog otrova, i uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj član je podjedinica integralnog glikoproteina membrane sperme, heterodimer zvanog fertilin, koji ima važnu ulogu u interakcijama spermatozoida i jajne ćelije.[8] Druga podjedinica je ADAM1 ili alfa-fertilin.[5]
Aminokiselinski sastav
10 20 30 40 50 MWRVLFLLSG LGGLRMDSNF DSLPVQITVP EKIRSIIKEG IESQASYKIV IEGKPYTVNL MQKNFLPHNF RVYSYSGTGI MKPLDQDFQN FCHYQGYIEG YPKSVVMVST CTGLRGVLQF ENVSYGIEPL ESSVGFEHVI YQVKHKKADV SLYNEKDIES RDLSFKLQSV EPQQDFAKYI EMHVIVEKQL YNHMGSDTV VAQKVFQLIG LTNAIFVSFN ITIILSSLEL WIDENKIATT GEANELLHTF LRWKTSYLVL RPHDVAFLLV YREKSNYVGA TFQGKMCDAN YAGGVVLHPR TISLESLAVI LAQLLLSLSMG ITYDDINKCQ CSGAVCIMNP EAIHFSGVKI FSNCSFEDFA HFISKQKSQC LHNQPRLDPF FKQQAVCGNA KLEAGEECDC GTEQDCALIG ETCCDIATCR FKAGSNCAEG PCCENCLFMS KERMCRPSFE ECDLPEYCNG SSASCPENHY VQTGHPCGLN QWICIDGVCM SGDKQCTDTF GKEVEFGPSE CYSHLNSKTD VSGNCGISDS GYTQCEADNL QCGKLICKYV GKFLLQIPRA TIIYANISGH LCIAVEFASD HADSQKMWIK DGTSCGSNKV CRNQRCVSSS YLGYDCTTDK CNDRGVCNNK KHCCSAYL PPDCSVQSDL WPGGSIDSGN FPPVAIPARL PERRYIENIY HSKPMRWPFF LFIPFFIIFC VLIAIMVKVN FQRKKWRTED YSSDEQPESE SEPKG
- A
- Alanin
- C
- Cistein
- D
- Asparaginska kiselina kiselina
- E
- Glutaminska kiselina
- F
- Fenilalanin
- G
- Glicin
- H
- Histidin
- I
- Izoleucin
- K
- Lizin
- L
- Leucin
- M
- Metionin
- N
- Asparagin
- P
- Prolin
- Q
- Glutamin
- R
- Arginin
- S
- Serin
- T
- Treonin
- V
- Valin
- W
- Triptofan
- Y
- Tirozin
Reference
- ^ a b c ENSG00000276286 GRCh38: Ensembl release 89: ENSG00000104755, ENSG00000276286 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022039 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (juni 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
- ^ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (juli 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. Bibcode:1996BBRC..224..318G. doi:10.1006/bbrc.1996.1027. PMID 8702389.
- ^ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (februar 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
- ^ a b "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".
Dodatni izvori
- Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y (maj 2002). "Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions". The Journal of Biological Chemistry. 277 (20): 17804–10. doi:10.1074/jbc.M200086200. PMID 11882657.
- Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M (decembar 2001). "Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility". Developmental Biology. 240 (1): 254–61. doi:10.1006/dbio.2001.0462. PMID 11784061.
- Cho C, Ge H, Branciforte D, Primakoff P, Myles DG (juni 2000). "Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion". Developmental Biology. 222 (2): 289–95. doi:10.1006/dbio.2000.9703. PMID 10837118.
- Chen MS, Tung KS, Coonrod SA, Takahashi Y, Bigler D, Chang A, Yamashita Y, Kincade PW, Herr JC, White JM (oktobar 1999). "Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization". Proceedings of the National Academy of Sciences of the United States of America. 96 (21): 11830–5. Bibcode:1999PNAS...9611830C. doi:10.1073/pnas.96.21.11830. PMC 18372. PMID 10518536.
- Chen H, Sampson NS (januar 1999). "Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta". Chemistry & Biology. 6 (1): 1–10. doi:10.1016/S1074-5521(99)80015-5. PMID 9889149.
- Vidaeus CM, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB, Herr JC (mart 1997). "Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member". Molecular Reproduction and Development. 46 (3): 363–9. doi:10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-#. PMID 9041139. S2CID 196584546.
- Dawson SJ, White LA (maj 1992). "Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin". The Journal of Infection. 24 (3): 317–20. doi:10.1016/S0163-4453(05)80037-4. PMID 1602151.
Vanjski linkovi
- The MEROPS online database for peptidases and their inhibitors: M12.950[mrtav link]
- Lokacija ljudskog genoma ADAM2 i stranica sa detaljima o genu ADAM2 u UCSC Genome Browseru.
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