ADAM22
Protein 22 koji sadrži domen dezintegrina i metaloproteinaze, također poznat kao ADAM22, je enzim koji je kod ljudi kodiran genom ADAM22.[5][6][7]
Aminokiselinska sekvenca
| 10 | 20 | 30 | 40 | 50 | ||||
| MQAAVAVSVP | FLLLCVLGTC | PPARCGQAGD | ASLMELEKRK | ENRFVERQSI | ||||
| VPLRLIYRSG | GEDESRHDAL | DTRVRGDLGG | PQLTHVDQAS | FQVDAFGTSF | ||||
| ILDVVLNHDL | LSSEYIERHI | EHGGKTVEVK | GGEHCYYQGH | IRGNPDSFVA | ||||
| LSTCHGLHGM | FYDGNHTYLI | EPEENDTTQE | DFHFHSVYKS | RLFEFSLDDL | ||||
| PSEFQQVNIT | PSKFILKPRP | KRSKRQLRRY | PRNVEEETKY | IELMIVNDHL | ||||
| MFKKHRLSVV | HTNTYAKSVV | NMADLIYKDQ | LKTRIVLVAM | ETWATDNKFA | ||||
| ISENPLITLR | EFMKYRRDFI | KEKSDAVHLF | SGSQFESSRS | GAAYIGGICS | ||||
| LLKGGGVNEF | GKTDLMAVTL | AQSLAHNIGI | ISDKRKLASG | ECKCEDTWSG | ||||
| CIMGDTGYYL | PKKFTQCNIE | EYHDFLNSGG | GACLFNKPSK | LLDPPECGNG | ||||
| FIETGEECDC | GTPAECVLEG | AECCKKCTLT | QDSQCSDGLC | CKKCKFQPMG | ||||
| TVCREAVNDC | DIRETCSGNS | SQCAPNIHKM | DGYSCDGVQG | ICFGGRCKTR | ||||
| DRQCKYIWGQ | KVTASDKYCY | EKLNIEGTEK | GNCGKDKDTW | IQCNKRDVLC | ||||
| GYLLCTNIGN | IPRLGELDGE | ITSTLVVQQG | RTLNCSGGHV | KLEEDVDLGY | ||||
| VEDGTPCGPQ | MMCLEHRCLP | VASFNFSTCL | SSKEGTICSG | NGVCSNELKC | ||||
| VCNRHWIGSD | CNTYFPHNDD | AKTGITLSGN | GVAGTNIIIG | IIAGTILVLA | ||||
| LILGITAWGY | KNYREQRQLP | QGDYVKKPGD | GDSFYSDIPP | GVSTNSASSS | ||||
| KKRSNGLSHS | WSERIPDTKH | ISDICENGRP | RSNSWQGNLG | GNKKKIRGKR | ||||
| FRPRSNSTET | LSPAKSPSSS | TGSIASSRKY | PYPMPPLPDE | DKKVNRQSAR | ||||
| LWETSI |
Funkcija
ADAM22 je član porodice ADAM (A Disintegrina Ai Metaloproteinaznog domena). Članovi ove porodice su proteini usidreni u membrani, strukturno srodni dezintegrinima zmijskog otrova dezintegrinima, i uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj gen je visoko eksprimiran u mozgu i može funkcionirati kao ligand integrina u mozgu. |Alternativno splajsovanje rezultira nekoliko transkriptnih varijanti.[7]
Interakcije
Pokazano je da ADAM22 inter-raguje sa DLG4[8]
Reference
- ^ a b c GRCh38: Ensembl release 89: ENSG00000008277 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040537 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Sagane K, Ohya Y, Hasegawa Y, Tanaka I (august 1998). "Metalloproteinase-like, disintegrin-like, cysteine-rich proteins MDC2 and MDC3: novel human cellular disintegrins highly expressed in the brain". The Biochemical Journal. 334 ( Pt 1) (Pt 1): 93–8. doi:10.1042/bj3340093. PMC 1219666. PMID 9693107.
- ^ Poindexter K, Nelson N, DuBose RF, Black RA, Cerretti DP (septembar 1999). "The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries". Gene. 237 (1): 61–70. doi:10.1016/S0378-1119(99)00302-9. PMID 10524237.
- ^ a b "Entrez Gene: ADAM22 ADAM metallopeptidase domain 22".
- ^ Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (septembar 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.
Dodatni izvori
- Harada T, Nishie A, Torigoe K, Ikezaki K, Shono T, Maehara Y, Kuwano M, Wada M (oktobar 2000). "The specific expression of three novel splice variant forms of human metalloprotease-like disintegrin-like cysteine-rich protein 2 gene inBrain tissues and gliomas". Japanese Journal of Cancer Research. 91 (10): 1001–6. doi:10.1111/j.1349-7006.2000.tb00877.x. PMC 5926265. PMID 11050470.
- Zhu Pc, Sun Y, Xu R, Sang Y, Zhao J, Liu G, Cai L, Li C, Zhao S (februar 2003). "The interaction between ADAM 22 and 14-3-3zeta: regulation of cell adhesion and spreading". Biochemical and Biophysical Research Communications. 301 (4): 991–9. Bibcode:2003BBRC..301..991Z. doi:10.1016/S0006-291X(03)00056-1. PMID 12589811.
- Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2). doi:10.1186/gb-2004-5-2-r8. PMC 395752. PMID 14759258.
- Sagane K, Hayakawa K, Kai J, Hirohashi T, Takahashi E, Miyamoto N, Ino M, Oki T, Yamazaki K, Nagasu T (2006). "Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice". BMC Neuroscience. 6. doi:10.1186/1471-2202-6-33. PMC 1142324. PMID 15876356.
- Zhu P, Sang Y, Xu H, Zhao J, Xu R, Sun Y, Xu T, Wang X, Chen L, Feng H, Li C, Zhao S (juni 2005). "ADAM22 plays an important role in cell adhesion and spreading with the assistance of 14-3-3". Biochemical and Biophysical Research Communications. 331 (4): 938–46. Bibcode:2005BBRC..331..938Z. doi:10.1016/j.bbrc.2005.03.229. PMID 15882968.
- D'Abaco GM, Ng K, Paradiso L, Godde NJ, Kaye A, Novak U (januar 2006). "ADAM22, expressed in normal brain but not in high-grade gliomas, inhibits cellular proliferation via the disintegrin domain". Neurosurgery. 58 (1): 179–86, discussion 179–86. doi:10.1227/01.NEU.0000192363.84287.8B. PMID 16385342. S2CID 24601244.
- Gödde NJ, D'Abaco GM, Paradiso L, Novak U (august 2006). "Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members". Journal of Cell Science. 119 (Pt 16): 3296–305. doi:10.1242/jcs.03065. PMID 16868027.
- Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M (septembar 2006). "Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission". Science. 313 (5794): 1792–5. Bibcode:2006Sci...313.1792F. doi:10.1126/science.1129947. PMID 16990550. S2CID 33024022.
- Chabrol E, Gourfinkel-An I, Scheffer IE, Picard F, Couarch P, Berkovic SF, McMahon JM, Bajaj N, Mota-Vieira L, Mota R, Trouillard O, Depienne C, Baulac M, LeGuern E, Baulac S (august 2007). "Absence of mutations in the LGI1 receptor ADAM22 gene in autosomal dominant lateral temporal epilepsy" (PDF). Epilepsy Research. 76 (1): 41–8. doi:10.1016/j.eplepsyres.2007.06.014. PMID 17681454. S2CID 28172409.[trajno mrtav link]
- Gödde NJ, D'Abaco GM, Paradiso L, Novak U (novembar 2007). "Differential coding potential of ADAM22 mRNAs". Gene. 403 (1–2): 80–8. doi:10.1016/j.gene.2007.07.033. PMID 17884303.
Vanjski linkovi
- The MEROPS online database for peptidases and their inhibitors: M12.978[mrtav link]
- Lokacija ljudskog genoma ADAM22 i stranica sa detaljima o genu ADAM22 u UCSC Genome Browseru.
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