ADAM33

ADAM33
Dostupne strukture
PDB	Pretraga ortologa: PDBe RCSB
Spisak PDB ID kodova
	1R54, 1R55
Identifikatori
Aliasi	ADAM33
Vanjski ID-jevi	OMIM: 607114 MGI: 1341813 HomoloGene: 11881 GeneCards: ADAM33
Lokacija gena (čovjek)
Hrom.	Hromosom 20 (čovjek)
Kraj	3,682,246 bp
Lokacija gena (miš)
Hrom.	Hromosom 2 (miš)
Kraj	130,905,734 bp
Ontologija gena
Molekularna funkcija	• GO:0070122 peptidase activity; • metalloendopeptidase activity; • GO:0001948, GO:0016582 vezivanje za proteine; • hydrolase activity; • metallopeptidase activity; • vezivanje iona metala; • vezivanje iona cinka;
Ćelijska komponenta	• integral component of membrane; • membrana;
Biološki proces	• Proteoliza;
	Izvori:Amigo / QuickGO
Ortolozi
	80332
	110751
	ENSG00000149451
	ENSMUSG00000027318
	Q9BZ11; Q08AM2
	Q923W9
	NM_001282447; NM_025220; NM_153202
	NM_001163529; NM_033615
	NP_001269376; NP_079496; NP_694882
	NP_001157001; NP_291093
	Wikipodaci
Pogledaj/uredi – čovjek	Pogledaj/uredi – miš

Protein 33 koji sadrži domen dezintegrina i metaloproteinaze je enzim koji je kod ljudi kodiran genom ADAM33.^[5]^[6]

Aminokiselinska sekvenca

C: Cistein

D: Asparaginska kiselina

E: Glutaminska kiselina

F: Fenilalanin

G: Glicin

H: Histidin

I: Izoleucin

K: Lizin

L: Leucin

M: Metionin

N: Asparagin

P: Prolin

Q: Glutamin

R: Arginin

S: Serin

T: Treonin

V: Valin

W: Triptofan

Y: Tirozin

10	20	30	40	50
MGWRPRRARG	TPLLLLLLLL	LLWPVPGAGV	LQGHIPGQPV	TPHWVLDGQP
WRTVSLEEPV	SKPDMGLVAL	EAEGQELLLE	LEKNHRLLAP	GYIETHYGPD
GQPVVLAPNH	TDHCHYQGRV	RGFPDSWVVL	CTCSGMSGLI	TLSRNASYYL
RPWPPRGSKD	FSTHEIFRME	QLLTWKGTCG	HRDPGNKAGM	TSLPGGPQSR
GRREARRTRK	YLELYIVADH	TLFLTRHRNL	NHTKQRLLEV	ANYVDQLLRT
LDIQVALTGL	EVWTERDRSR	VTQDANATLW	AFLQWRRGLW	AQRPHDSAQL
LTGRAFQGAT	VGLAPVEGMC	RAESSGGVST	DHSELPIGAA	ATMAHEIGHS
LGLSHDPDGC	CVEAAAESGG	CVMAAATGHP	FPRVFSACSR	RQLRAFFRKG
GGACLSNAPD	PGLPVPPALC	GNGFVEAGEE	CDCGPGQECR	DLCCFAHNCS
LRPGAQCAHG	DCCVRCLLKP	AGALCRQAMG	DCDLPEFCTG	TSSHCPPDVY
LLDGSPCARG	SGYCWDGACP	TLEQQCQQLW	GPGSHPAPEA	CFQVVNSAGD
AHGNCGQDSE	GHFLPCAGRD	ALCGKLQCQG	GKPSLLAPHM	VPVDSTVHLD
GQEVTCRGAL	ALPSAQLDLL	GLGLVEPGTQ	CGPRMVCQSR	RCRKNAFQEL
QRCLTACHSH	GVCNSNHNCH	CAPGWAPPFC	DKPGFGGSMD	SGPVQAENHD
TFLLAMLLSV	LLPLLPGAGL	AWCCYRLPGA	HLQRCSWGCR	RDPACSGPKD
GPHRDHPLGG	VHPMELGPTA	TGQPWPLDPE	NSHEPSSHPE	KPLPAVSPDP
QADQVQMPRS	CLW

Funkcija

Ovaj gen kodira člana porodice ADAM (domen dezintegrina i metaloproteinaze). Članovi ove porodice su membranski usidreni proteini, strukturno srodni zmijskim otrovima dezintegrinima i uključeni su u različite biološke procese koji uključuju interakcije ćelija-ćelija i ćelija-matriks, uključujući oplodnju, razvoj mišića i neurogenezu. Ovaj protein je transmembranski protein tipa I uključen u astmu i bronhijsku hiperreaktivnost.^[7] Alternativno splajsovanje ovog gena rezultira u dvije transkriptne varijante koje kodiraju različite izoforme.^[6]

Reference

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149451 - Ensembl, maj 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000027318 - Ensembl, maj 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (januar 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–236. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.
^ ^a ^b "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".
^ Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM (21. 7. 2016). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight (jezik: engleski). 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

Dodatni izvori

Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW (august 2004). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical Reviews in Allergy & Immunology. 27 (1): 23–34. doi:10.1385/CRIAI:27:1:023. PMID 15347848. S2CID 23971367.
Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST (august 2004). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert Reviews in Molecular Medicine. 6 (17): 1–12. doi:10.1017/S1462399404007963. PMID 15387895. S2CID 30427584.
Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE (juli 2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–443. doi:10.1513/pats.200603-026AW. PMID 16799089.
Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, Bawa A, Saracino L, Thackston M, Benchekroun Y, Capparell N, Wang M, Adair R, Feng Y, Dubois J, FitzGerald MG, Huang H, Gibson R, Allen KM, Pedan A, Danzig MR, Umland SP, Egan RW, Cuss FM, Rorke S, Clough JB, Holloway JW, Holgate ST, Keith TP (juli 2002). "Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness". Nature. 418 (6896): 426–430. doi:10.1038/nature00878. PMID 12110844. S2CID 4424215.
Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, Shah H, Wan Y, Motasim Billah M, Egan RW, Umland SP (januar 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. doi:10.1016/S0006-291X(02)02976-5. PMID 12535637.
Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". Journal of Human Genetics. 48 (5): 278–281. doi:10.1007/s10038-003-0019-1. PMID 12768445.
Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA (oktobar 2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". The Journal of Allergy and Clinical Immunology. 112 (4): 717–722. doi:10.1016/s0091-6749(03)01939-0. PMID 14564349.
Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V (januar 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–137. doi:10.1016/j.jmb.2003.10.037. PMID 14659745.
Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP (mart 2004). "Catalytic activity of human ADAM33". The Journal of Biological Chemistry. 279 (11): 9818–9830. doi:10.1074/jbc.M309696200. PMID 14676211.
Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE (juli 2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". American Journal of Respiratory Cell and Molecular Biology. 31 (1): 13–21. doi:10.1165/rcmb.2003-0330OC. PMID 14742294.
Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE (maj 2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". American Journal of Respiratory and Critical Care Medicine. 171 (9): 958–965. doi:10.1164/rccm.200409-1251OC. PMID 15709049.
Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP (mart 2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–4256. doi:10.1021/bi0476230. PMID 15766253.
Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, Woodcock A, Ollier WE, Collins A, Custovic A, Holloway JW, John SL (juli 2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". American Journal of Respiratory and Critical Care Medicine. 172 (1): 55–60. doi:10.1164/rccm.200412-1708OC. PMID 15805180.

Vanjski linkovi

The MEROPS online database for peptidases and their inhibitors: M12.244^{[mrtav link]}
Lokacija ljudskog genoma ADAM33 i stranica sa detaljima o genu ADAM33 u UCSC Genome Browseru.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000149451 - Ensembl, maj 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000027318 - Ensembl, maj 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Yoshinaka_2002-5] Yoshinaka T, Nishii K, Yamada K, Sawada H, Nishiwaki E, Smith K, Yoshino K, Ishiguro H, Higashiyama S (januar 2002). "Identification and characterization of novel mouse and human ADAM33s with potential metalloprotease activity". Gene. 282 (1–2): 227–236. doi:10.1016/S0378-1119(01)00818-6. PMID 11814695.

[entrez-6] "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".

[7] Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM (21. 7. 2016). "Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life". JCI Insight (jezik: engleski). 1 (11). doi:10.1172/jci.insight.87632. ISSN 0021-9738. PMC 4968941. PMID 27489884.

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p r u Proteaze: metaloendopeptidaze (EC 3.4.24)
ADAM-proteini	Alfa sekretaza ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matriksne metaloproteinaze	Kolagenaze MMP1 MMP8 Želatinaze MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Ostali	Neprilizin Prokolagenska peptidaza Termolizin Plazmatski protein A povezan s trudnoćom Kostni morfogenetski protein 1 Lizostafin Insulin razgrađujući enzim ZMPSTE24