FCGRT
| Fc fragment of IgG receptor and transporter | |||||||
|---|---|---|---|---|---|---|---|
| معرفات | |||||||
| أسماء بديلة | transmembrane alpha chain of the neonatal receptor, Fc fragment of IgG, receptor, transporter, alpha, Neonatal Fc receptor, IgG receptor FcRn large subunit p51, neonatal Fc-receptor for Ig, heavy chain of the major histocompatibility complex class I-like Fc receptor, major histocompatibility complex class I-like Fc receptor, FCGRT, FcRn alpha chain, IgG Fc fragment receptor transporter alpha chain, immunoglobulin receptor, intestinal, heavy chain | ||||||
| معرفات خارجية | |||||||
| تماثلات متسلسلة | |||||||
| أنواع | الإنسان | الفأر | |||||
| أنتريه | n/a | ||||||
| Ensembl | n/a | n/a | |||||
| يونيبروت |
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| RefSeq (رنا مرسال.) |
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| RefSeq (بروتين) |
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| الموقع (UCSC | n/a | ||||||
| بحث ببمد | n/a | ||||||
| ويكي بيانات | |||||||
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FCGRT (Fc fragment of IgG receptor and transporter) هوَ بروتين يُشَفر بواسطة جين FCGRT في الإنسان.[1][2][3]
الوظيفة
![[أيقونة]](https://infokontak.com/ar/%D9%85%D9%84%D9%81:Crystal_xedit.svg){kind=small} | هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
الأهمية السريرية
| هذا القسم فارغ أو غير مكتمل. ساهم في توسيعه. (يوليو 2018) |
المراجع
- ^ "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha". مؤرشف من الأصل في 2010-12-05.
- ^ Story CM، Mikulska JE، Simister NE (ديسمبر 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J. Exp. Med. ج. 180 ع. 6: 2377–81. DOI:10.1084/jem.180.6.2377. PMC:2191771. PMID:7964511.
- ^ Kandil E، Egashira M، Miyoshi O، Niikawa N، Ishibashi T، Kasahara M، Miyosi O (يوليو 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet. Cell Genet. ج. 73 ع. 1–2: 97–8. DOI:10.1159/000134316. PMID:8646894.
قراءة متعمقة
- Dürrbaum-Landmann I، Kaltenhäuser E، Flad HD، Ernst M (1994). "HIV-1 envelope protein gp120 affects phenotype and function of monocytes in vitro". J. Leukoc. Biol. ج. 55 ع. 4: 545–51. PMID:8145026.
- Leach JL، Sedmak DD، Osborne JM، Rahill B، Lairmore MD، Anderson CL (1996). "Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport". J. Immunol. ج. 157 ع. 8: 3317–22. PMID:8871627.
- Kivelä J، Parkkila S، Waheed A، Parkkila AK، Sly WS، Rajaniemi H (1997). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum". Clin. Chem. ج. 43 ع. 12: 2318–22. PMID:9439449.
- Vaughn DE، Bjorkman PJ (1998). "Structural basis of pH-dependent antibody binding by the neonatal Fc receptor". Structure. ج. 6 ع. 1: 63–73. DOI:10.1016/S0969-2126(98)00008-2. PMID:9493268.
- West AP، Bjorkman PJ (2000). "Crystal structure and immunoglobulin G binding properties of the human major histocompatibility complex-related Fc receptor(,)". Biochemistry. ج. 39 ع. 32: 9698–708. DOI:10.1021/bi000749m. PMID:10933786.
- Mikulska JE، Pablo L، Canel J، Simister NE (2000). "Cloning and analysis of the gene encoding the human neonatal Fc receptor". Eur. J. Immunogenet. ج. 27 ع. 4: 231–40. DOI:10.1046/j.1365-2370.2000.00225.x. PMID:10998088.
- Zhu X، Meng G، Dickinson BL، Li X، Mizoguchi E، Miao L، Wang Y، Robert C، Wu B، Smith PD، Lencer WI، Blumberg RS (2001). "MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells". J. Immunol. ج. 166 ع. 5: 3266–76. DOI:10.4049/jimmunol.166.5.3266. PMC:2827247. PMID:11207281.
- Ober RJ، Radu CG، Ghetie V، Ward ES (2001). "Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies". Int. Immunol. ج. 13 ع. 12: 1551–9. DOI:10.1093/intimm/13.12.1551. PMID:11717196.
- Praetor A، Hunziker W (2002). "beta(2)-Microglobulin is important for cell surface expression and pH-dependent IgG binding of human FcRn". J. Cell Sci. ج. 115 ع. Pt 11: 2389–97. PMID:12006623.
- Claypool SM، Dickinson BL، Yoshida M، Lencer WI، Blumberg RS (2002). "Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin". J. Biol. Chem. ج. 277 ع. 31: 28038–50. DOI:10.1074/jbc.M202367200. PMC:2825174. PMID:12023961.
{{استشهاد بدورية محكمة}}: صيانة الاستشهاد: دوي مجاني غير معلم (link) - Praetor A، Jones RM، Wong WL، Hunziker W (2002). "Membrane-anchored human FcRn can oligomerize in the absence of IgG". J. Mol. Biol. ج. 321 ع. 2: 277–84. DOI:10.1016/S0022-2836(02)00626-5. PMID:12144784.
- Shah U، Dickinson BL، Blumberg RS، Simister NE، Lencer WI، Walker WA (2003). "Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine". Pediatr. Res. ج. 53 ع. 2: 295–301. DOI:10.1203/01.pdr.0000047663.81816.e3. PMC:2819091. PMID:12538789.
- Chaudhury C، Mehnaz S، Robinson JM، Hayton WL، Pearl DK، Roopenian DC، Anderson CL (2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. ج. 197 ع. 3: 315–22. DOI:10.1084/jem.20021829. PMC:2193842. PMID:12566415.
- Schilling R، Ijaz S، Davidoff M، Lee JY، Locarnini S، Williams R، Naoumov NV (2003). "Endocytosis of hepatitis B immune globulin into hepatocytes inhibits the secretion of hepatitis B virus surface antigen and virions". J. Virol. ج. 77 ع. 16: 8882–92. DOI:10.1128/JVI.77.16.8882-8892.2003. PMC:167249. PMID:12885906.
- Zhou J، Johnson JE، Ghetie V، Ober RJ، Ward ES (2003). "Generation of mutated variants of the human form of the MHC class I-related receptor, FcRn, with increased affinity for mouse immunoglobulin G". J. Mol. Biol. ج. 332 ع. 4: 901–13. DOI:10.1016/S0022-2836(03)00952-5. PMID:12972260.
- Cianga P، Cianga C، Cozma L، Ward ES، Carasevici E (2003). "The MHC class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland". Hum. Immunol. ج. 64 ع. 12: 1152–9. DOI:10.1016/j.humimm.2003.08.025. PMID:14630397.
- Ober RJ، Martinez C، Vaccaro C، Zhou J، Ward ES (2004). "Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn". J. Immunol. ج. 172 ع. 4: 2021–9. DOI:10.4049/jimmunol.172.4.2021. PMID:14764666.
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